The women experienced significant improvements in insomnia, anxiety, mood, and irritability (31). A recent study demonstrated that a magnolia/phellodendron bark supplement reduced stress-related eating in 56 moderately-stressed participants. This article reviews the, Sorrel, which refers to both a leafy green plant and its fruit, is known for its tart taste and powerful health benefits. When alarm protein galectin-3 gets activated in response to stress, it kicks off a series of inflammatory reactions. They do it by peeling or cutting the bark from the roots, stems, and branches of the tree. Additionally, the magnolol appeared to increase the number of times the mice woke up during sleep but decrease the length of time they were awake. Magnolia bark has been used in traditional Japanese and Chinese medicine for thousands of years. What if we could use our minds to reduce galectin-3? A 24-week study in 89 menopausal women experiencing symptoms of sleep and mood alterations were given a supplement containing 60 mg of magnolia bark extract and 50 mg of magnesium daily. Getting adequate amounts of deep sleep is key for mental and physical health. Nevertheless, amid the wide range of personalized treatments, there remain a handful of powerful integrative therapies that continue to demonstrate remarkableresults against cancer, regardless of the type or stage. Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, induces sleep via the benzodiazepine site of GABA(A) receptor in mice. Magnolia. Chewing gum with magnolia bark extract may promote better breath and gum health. California Sycamore. Magnolol and honokiol achieve this effect by improving the intestinal movement that helps move digested food through the gastrointestinal tract. Nine phenylethanoid glycosides from Magnolia officinalis var. One way in which honokiol may combat cancer is by helping regulate cell signaling pathways. Magnolia helps in preventing fat from building up around the liver. are clickable links to these studies. In cases of aggressive cancer, a more intensive treatment called Therapeutic Apheresis can also be used. There are so many ways that chronic stress harms your body, mind, and mood. Magnolia bark is a popular herb used for gut health and stress-induced anxiety. Is Garcinia Cambogia Safe for Weight Loss? 26 were here. Cissus quadrangularis: Uses, Benefits, Side Effects, and Dosage, Galangal Root: Benefits, Uses, and Side Effects. By disrupting galectin-3s protective mechanisms, we also allow other therapies conventional and holistic to reach the tumor for greater anti-cancer benefits. 9. The overreactions can leave you struggling with autoimmune disease symptoms. In Kampo or traditional Japanese medicine, magnolia bark was also used for gastrointestinal support. Effect of a proprietary Magnolia and Phellodendron extract on weight management: a pilot, double-blind, placebo-controlled clinical trial. The Journal of pharmacy and pharmacology, 73(9), 11611168. British journal of pharmacology, 167(3), 587598. (2020). There are many potential health benefits of magnolia bark offered by two key micronutrients magnolol and honokiol present in it. Among them, magnolol and honokiol are the main nutrients in magnolia bark with the most medicinal value. All rights reserved. During the 7th century, monks in the Chinese Buddhist temples grew these trees in their gardens for use in treating conditions like depression, asthma, muscle pain, and headache. The supplement can be found at many online and retail stores. If you decide to take magnolia bark, carefully read the manufacturers instructions to know how much to take and how often. 220 A.D.). Cultivation and therapeutic use also date back to the Native Americans and ancient Aztecs. Chemopreventive effects of honokiol on UVB-induced skin cancer development. Here are common signs of too much stress. Honokiol inhibits in vitro and in vivo growth of oral squamous cell carcinoma through induction of apoptosis, cell cycle arrest and autophagy. The Extraordinary Importance of Sleep: The Detrimental Effects of Inadequate Sleep on Health and Public Safety Drive an Explosion of Sleep Research. Currently, magnolia bark is widely used in food supplements and beauty products.You can also find the bark's name listed in the American Pharmacopeia as a bitter antimalarial tonic. Exception of use under qualified healthcare practitioner supervision. This not only includes brain disorders like Alzheimers disease but also conditions like stress, anxiety, mood disorders, and depression (23). It was also valued in TCM for its ability to reduce inflammation, anxiety, and bloating.. https://doi.org/10.1021/np800494e, Siegel, R. L., Miller, K. D., & Jemal, A. Magnolia bark benefits gut health and healthy digestion. Impacts of gut bacteria on human health and diseases. Those gentle detox abilities make it easier for your body to cope with other challenges, including chronic stress. The genus of the tree was named after the French physician, Pierre Magnol, who was a well-regarded botanist in the 17th century. Coping with stress is a full-time job, and your body needs all the support it can get. Plus, long-term stress adds an extra strain on your body. https://doi.org/10.2147/OTT.S168887. Magnolia bark is a popular herb in traditional Chinese and Japanese medicine. Since ancient times, herbs have been used as natural remedies for a variety of viral infections. Read on for proven tactics. When the danger passes, the system turns off and resets. Balanced bacteria in the gut promotes healthy digestion, as well as improved mental health. Safety and Toxicology of Magnolol and Honokiol. A second study of the same magnolia and phellodendron bark extract in 56 adults observed that consuming 500 mg of the extract per day resulted in significantly lower cortisol levels and improved mood (25). Perky Calm & Alert Backyard Medicinal Herbs. Researchers ensured that there was a steady dose of honokiol throughout the study (while the other ingredients varied) in order to confirm their hypothesis. Therefore, it isn't possible to say if the side effects were due to metformin or pine pollen. https://doi.org/10.1211/0022357001777432, Lloyd & Lloyd (1887). Therefore, magnolia bark could be used as a remedy for insomnia or simply to promote better sleep overall. Along with these health benefits, the bark also has strong potential for weight loss, reducing inflammation, and improving sleep. Doing so may cause drowsiness and make it unsafe for you to drive or use heavy machinery., Alternative Therapies in Health and Medicine: Effect of a proprietary Magnolia and Phellodendron extract on weight management: a pilot, double-blind, placebo-controlled clinical trial., Current Microbiology: The Therapeutic Effects ofMagnolia Officinalis Extraction on an Antibiotics-Induced Intestinal Dysbacteriosis in Mice., Institute for Traditional Medicine: MAGNOLIA BARK., Journal of the International Society of Sports Nutrition: Effect ofMagnolia officinalis andPhellodendron amurense (Relora) on cortisol and psychological mood state in moderately stressed subjects., Journal of Zhejiang University. Magnolol exerts anticancer activity in hepatocellular carcinoma cells through regulating endoplasmic reticulum stress-mediated apoptotic signaling. Chronic stress makes you feel awful mentally, emotionally, and physically. Decoction of the bark, capsules, and TCM/Kampo blends are the most common preparations used for different types of ailments. Effect of Magnolia officinalis and Phellodendron amurense (Relora) on cortisol and psychological mood state in moderately stressed subjects. Excess stress is a common problem. Copyright2023 Healthy Lifestyle Brands, LLC. When we address unhealthy galectin-3 expression with proven methods, we effectively treat not just cancer, but numerous life-threatening conditions as well. Today, magnolia bark extract is readily available in pill form. Some of the benefits of magnolia bark, such as improved sleep and mood, could be especially beneficial for women during menopause (30). A study in mice found a magnolol dose of 2.30.9 mg per pound (525 mg per kg) of body weight significantly decreased sleep latency, or the amount of time it takes to fall asleep (27). Once their inner surface turns dark brown or purplish brown, the TCM practitioners steam, roll, and dry them. These two compounds come under the category of polyphenols plant micronutrients that offer health benefits like defense against UV radiation and microbial infection.. Nevertheless, magnolia bark appears to be a safe therapy that may help treat menopause symptoms. Note that the numbers in parentheses (1, 2, etc.) This article reviews what it is, its best uses, potential benefits, and side, Suma root has many medicinal uses in folk medicine, but scientific evidence supporting its purported benefits is lacking. In fact, magnolia bark is thought to be one of the best herbs for sleep. To date, scientists have found over 250 chemical compounds in the bark, flowers, cones, and leaves of the genus Magnolia. If cancer is smart, we have to be brilliant and with leading-edge integrative strategies, we can be. For example, because magnolia bark supplements may promote sleep in some individuals, its probably best not to take the supplements in combination with any other type of sedative or sleeping pill. Cancer is one of the leading causes of death worldwide. Yoga: Practicing yoga promotes relaxation for your mind and body. Because, obviously, we want to survive any life-threatening condition. In addition to this, the mice spent more time in deep sleep resulting in an overall higher quality of sleep. The magnolia is a deciduous tree that has multiple species that are native to eastern Asia, as well as the Americas. Magnolia bark has been used for centuries to treat digestive problems, including nausea, abdominal pain and bloating, diarrhea, and loss of appetite. Our website content is for informational purposes only. Grandchildren are some of lifes greatest treasures. So go for a walk, take a bike ride, or dance around the room and let those endorphins kick in. It may also possess anti-cancer effects in higher doses. Research shows that a number of healthy stress relief strategies, including those listed below, also offer protection against Alzheimers and other forms of cognitive decline. https://doi.org/10.1093/jpp/rgab067, Chen, C. R., Zhou, X. In a clinical trial involving healthy, overweight, premenopausal women, Magnolia officinalis extract (MOE) demonstrated a weight loss effect on those that overate when they were stressed. The bark then undergoes a process of drying and boiling before its infused into a tincture for oral consumption. A similar study in more than 600 menopausal women found that consuming a magnolia bark supplement daily for 12 weeks relieved symptoms of insomnia, irritability, and anxiety (32). BioMed research international, 2021, 6688414. https://doi.org/10.1155/2021/6688414, Wang, Y. D., Sun, X. J., Yang, W. J., Li, J., & Yin, J. J. Researchers attributed these effects to honokiols potential to reduce anxiety and stress. With over 50 published studies and counting, researchers at Harvard, the NIH and other renowned institutes are increasingly interested in the singular ability of this MCP to halt and reverse the devastating actions of galectin-3, in cancer as well as heart disease, kidney failure, arthritis and much more. Honokiol was able to prevent cell growth while inducing cancer cell death. Effects of magnolol and honokiol derived from traditional Chinese herbal remedies on gastrointestinal movement. The safest way to get magnesium is by eating a diet filled with magnesium-rich foods. Modified Citrus Pectin Formula - Dr. Isaac Eliaz The most advanced and effective solution for health, aging and longevityClinically Researched Modified Citrus Pectin. At the same time, fascinating research continues to unravel the vast network of mechanisms that connect our mind and emotions to our physical health. In fact, eye-opening research shows a direct link between galectin-3 and depression, making this alarm protein a strong potential target in treating stress-related mental illness. Zhang, W. W., Li, Y., Wang, X. Q., Tian, F., Cao, H., Wang, M. W., & Sun, Q. S. (2005). Benefit 5 - Brain Health Healthy sleep is essential for cognitive performance. Researchers found that MOE reduced evening cortisol levels, a stress marker, which led to a decrease in nighttime snacking. Science. Furthermore, honokiol may not only have anticancer properties itself but also help increase the effectiveness of other anticancer and radiation drug therapies (18, 19). He needed to be stabilized, and then an impossible rehabilitation awaited. In: StatPearls [Internet]. This dried bark known for its sharp smell and bitter taste is then soaked in a traditional medicine tincture for oral use. Along with increasing your overall resilience, MCP blocks galectin-3, the alarm protein that triggers inflammation and causes many of the harmful effects associated with chronic stress. | Henriette's Herbal Homepage. This makes sense, since galectin-3 functions as the master alarm that sounds off ceaselessly when the body is under stress. You can also try these other integrative recommendations for dealing with depression. This provider currently accepts 37 insurance plans including Medicare and Medicaid. Through many of the same mechanisms that it supports sleep by, magnolia bark can help reduce anxiety by activating receptors in the endocannabinoid system (like CBD) and reducing adrenaline and other stress hormones like cortisol. The supplement can not only help improve sleep, stress, anxiety, and symptoms of menopause but also may have anticancer and antioxidant properties. A modern herbal. Use a combination of these stress-reducing methods to calm down your mind and body no matter what life throws at you. Other common names include Cucumber Tree, Magnoliae cortex, Swamp Sassafras, Houpo, and Honoki. These responses are a natural part of our immediate survival drive, but over time, they fuel inflammation, degeneration and cancer progression. It's most well-known for boosting liver function and helping with adrenal functions, but other benefits also include: acting like a powerful brain tonic (improving focus, concentration, memory and mental energy) improving digestion supporting hormonal balance nourishing the skin Magnolia bark has been used for centuries in traditional Chinese medicine to treat an array of conditions including depression, anxiety, and sleep issues like insomnia. But when you face stressors all the time work deadlines, traffic jams, bad news the system cant turn off. Cincinnati, OH: Ohio Valley Co. Retrieved from: https://www.henriettes-herb.com/eclectic/cook/MAGNOLIA_GLAUCA.htm. If you decide to supplement with magnolia bark, carefully follow the manufacturers instructions regarding how much to take and how often. Honokiol, a natural biphenyl, inhibits in vitro and in vivo growth of breast cancer through induction of apoptosis and cell cycle arrest. In order to stay ahead of the disease, we have to outwit it at every turn. The calming effects are unlike anything we have come across and produce a very comprehensive effect. https://doi.org/10.3748/wjg.v11.i28.4414, Zhang, Y. J., Li, S., Gan, R. Y., Zhou, T., Xu, D. P., & Li, H. B. Typically, magnolia bark is bark of the houpo magnolia tree that has been stripped away from it branches and stems to make supplements. Current microbiology, 77(9), 24132421. Regular yoga practice helps regulate your nervous system and reduces the harmful effects of stress. (1999). Learn more. For more than 30 years, Ive specialized in the integrative treatment of cancer, designing individualized protocols that combine diverse modalities into a comprehensive care plan based on each patients unique story. The bark is particularly rich in two neolignans that are believed to be responsible for its medicinal properties magnolol and honokiol (1, 2). This tree belongs to the Magnoliaceae family and can grow to a mature height from 16 ft up to 80 ft. You can easily identify the magnolia tree from its large and fragrant flowers that often reach 8 inches in diameter. or Healthy Lifestyle Brands. Healing Sleep: The Art and Science of Sleep. The TCM practitioners steam, roll, and irritability ( 31 ): Practicing yoga promotes for. Of drying and boiling before its infused into a tincture for oral consumption best herbs for sleep were to. Manufacturers instructions to know how much to take magnolia bark, carefully the! 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