This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Tulsi is an aromatic shrub in the basil family Lamiaceae (tribe ocimeae) that is thought to have originated in north central India and now grows native throughout the eastern world tropics. Therapy with methanolic extract of Pterocarpus marsupium Roxb and Ocimum sanctum Linn reverses dyslipidemia and oxidative stress in alloxan induced type I diabetic rat model. Saxena RC, Singh R, Kumar P, Negi MP, Saxena VS, Geetharani P, et al. Tulsi is perhaps one of the best examples of Ayurveda's holistic lifestyle approach to health. [10,11], Tulsi also helps to prevent cancers caused by toxic compounds by reducing DNA damage[12] and inducing apoptosis in precancerous and cancerous cells, thereby reducing the growth of experimental tumors and enhancing survival. Wake Up Before It Is Too Late: Make Agriculture Truly Sustainable Now for Food Security in a Changing Climate; Geneva, United Nations. The anti-inflammatory action of tulsi, which has been observed in both acute and chronic inflammatory models in animals,[62,63,64,65] is attributed to tulsi's eugenol and linoleic acid content and the inhibition of both the cyclooxygenase and the lipoxygenase pathways of arachidonic acid metabolism. Agrawal P, Rai V, Singh RB. There is a growing realization that in order to tackle issues of food security, rural poverty, hunger, environmental degradation and climate change a shift in agriculture is needed from a green revolution to an ecological intensification revolution. Sadekar RO, Pimprikar NM, Bhandarkar AG, Barmase BS. Singh S, Majumdar DK. Tulsi is further integrated into daily life through evening and morning rituals and other spiritual and purification practices that can involve ingesting its leaves or consuming tulsi tea. Immunomodulatory activity of, Goel A, Singh DK, Kumar S, Bhatia AK. Double-blinded randomized controlled trial for immunomodulatory effects of Tulsi (Ocimum sanctum Linn.) There is mounting evidence that tulsi can address physical, chemical, metabolic and psychological stress through a unique combination of pharmacological actions. School of Health Sciences, RMIT University, Victoria, Australia. Manikandan P, Murugan RS, Abbas H, Abraham SK, Nagini S. Ocimum sanctum Linn. Received 2014 Jun 9; Revised 2014 Jul 15; Accepted 2014 Aug 11. These studies reveal that tulsi has a unique combination of actions that include: Antimicrobial (including antibacterial, antiviral, antifungal, antiprotozoal, antimalarial, anthelmintic), mosquito repellent, anti-diarrheal, anti-oxidant, anti-cataract, anti-inflammatory, chemopreventive, radioprotective, hepato-protective, neuro-protective, cardio-protective, anti-diabetic, anti-hypercholesterolemia, anti-hypertensive, anti-carcinogenic, analgesic, anti-pyretic, anti-allergic, immunomodulatory, central nervous system depressant, memory enhancement, anti-asthmatic, anti-tussive, diaphoretic, anti-thyroid, anti-fertility, anti-ulcer, anti-emetic, anti-spasmodic, anti-arthritic, adaptogenic, anti-stress, anti-cataract, anti-leukodermal and anti-coagulant activities. These practices include consumption of fresh, minimally processed foods, the use of Rasayanas (formulas) that eradicate ageing and disease, sophisticated detoxification practices and regular consumption of adaptogenic herbs that enhance the body's capacity to maintain balance in the midst of a variety of stressors. Protective effect of. [70], Modern research has revealed that tulsi has anti-bacterial, anti-viral and anti-fungal activity[71] that includes activity against many pathogens responsible for human infections. This emerging science on tulsi, which reinforces ancient Ayurvedic wisdom, suggests that tulsi is a tonic for the body, mind and spirit that offers solutions to many modern day health problems. Tabassum I, Siddiqui ZN, Rizvi SJ. Antibacterial properties of garlic and tulsi in repeat breeding crossbred cows. official website and that any information you provide is encrypted Nayak V, Devi PU. International Journal of Pharma and Bio Sciences. Ahmad MZ, Ali M, Mir SR. Anti-diabetic activity of Ocimum sanctum L. roots and isolation of new phytoconstituents using two-dimensional nuclear magnetic resonance spectroscopy. Lahon K, Das S. Hepatoprotective activity of, Pemminati S, Nair V, Dorababu P, Gopalakrishna HN, Pai MR. Effect of ethanolic leaf extract of, Ubaid RS, Anantrao KM, Jaju JB, Mateenuddin M. Effect of, Karamala SK, Srilatha C, Anjaneyulu Y, ChandraSekharaRao TS, Sreenivasulu D, Pidugu AP. [25,112,113,114] This anti-ulcer activity is attributed to multiple actions including the reduction of offensive factors such as acid-pepsin secretion and lipid peroxidation and the enhancement of gastric defensive factors such as mucin secretion, cellular mucus and longevity of mucosal cells.[114,115]. In less-formal situations, many people ritualize their morning cup of coffee and use the meet-up for coffee to arrange their social agendas, while the tea break is often built into the modern-day work routine. Fernndez PB, Figueredo YN, Dominguez CC, Hernndez IC, Sanabria MLG, Gonzlez R, et al. Malhotra R, Grover V, Kapoor A, Saxena D. Comparison of the effectiveness of a commercially available herbal mouthrinse with chlorhexidine gluconate at the clinical and patient level. Singh S, Majumdar DK. Comparative pharmacological evaluation of Ocimum sanctum and imipramine for antidepressant activity. Effect of Ocimum sanctum, turmeric extract and vitamin E supplementation on the salivary gland and bone marrow of radioiodine exposed mice. We are one of the leading manufacturer and exporter of a wide range of Wooden box.We are supplier of Wooden box,Plywood box and Marble packing box in udaipur(Rajasthan),India. Hepatoprotective and antioxidant activities of crude fractions of endophytic fungi of. Goel RK, Sairam K, Dorababu M, Prabha T, Rao CV. Anti inflammatory activity of fresh tulsi leaves (. Shukla ST, Kulkarni VH, Habbu PV, Jagadeesh KS, Patil BS, Smita DM. [66,67] This enables tulsi to exert anti-inflammatory effects comparable to nonsteroidal anti-inflammatory drugs such as phenylbutazone,[68] ibuprofen, naproxen, aspirin[69] and indomethacin. (Holy Basil) ethanolic leaf extract protects against 7,12-dimethylbenz (a) anthracene-induced genotoxicity, oxidative stress, and imbalance in xenobiotic-metabolizing enzymes. we are a Sole Proprietorship company and manufacture these products as per the set industry standards. Metabolic stress due to poor diet, low physical activity and psychological stress is a prominent feature of modern lifestyles and metabolic syndrome is estimated to affect as much as one-third of modern populations. We are acknowledged as one amidst the remarkable manufacturers pallets Suppliers from Rajasthan, India. We are engaged in manufacturing and exporting a wide assortment of wooden pallet,plywood pallet,plywood box,wooden box,industrieal wooden packging. Ameliorative effect of Ocimum Sanctum on meloxicam induced toxicity in wistar rats. Immunomodulatory activity and Th1/Th2 cytokine response of, Tripathi AK, Rajora VS, Gupta DK, Shukla SK. Sembulingam K, Sembulingam P, Namasivayam A. In Hinduism, tulsi is worshipped as a goddess and every part of the tulsi plant is revered and considered sacred, including the leaves, stem, flower, root, seeds and oil. Reshma K, Rao AV, Dinesh M, Vasudevan DM. Singh S, Malhotra M, Majumdar DK. Rajamma AJ, Dubey S, Sateesha SB, Tiwari SN, Ghosh SK. Moinuddin G, Devi K, Satish H, Khajuria DK. Antibacterial activity of, Mandal S, Mandal MD, Pal NK. Conflict of Interest: The author receives remuneration as a consultant and advisor to Organic India Pvt. Effects of Ocimum sanctum and Camellia sinensis on stress-induced anxiety and depression in male albino Rattus norvegicus. Pemminati S, Gopalakrishna HN, Venkatesh V, Rai A, Shetty S, Vinod A, et al. We are one of the esteemed manufacturer of two way, four way, jungle wood and pine wood pallets. [32,33,34,35] Tulsi exerts its radio-protective effects by scavenging free radicals and reducing the oxidative cellular and chromosomal damage induced by radiation,[33,36,37,38] thereby reducing organ damage and enhancing postradiation survival in experimental animals.[39,40,41]. Reddy SS, Karuna R, Baskar R, Saralakumari D. Prevention of insulin resistance by ingesting aqueous extract of Ocimum sanctum to fructose-fed rats. Tulsi has also been shown to boost defenses against infective threats by enhancing immune responses in nonstressed and stressed animals[72,73,74,75,76,77] and healthy humans. [28], In addition to protecting against toxic chemicals, tulsi has also been shown to protect against the toxic effects of heavy metals such as lead, arsenic, cadmium, chromium and mercury[29,30,31] and the toxic effects of radiation. 8600 Rockville Pike Anti-inflammatory effect of lyophilized aqueous extract of Ocinum tenuiflorum on rats. An official website of the United States government. Joseph LJ, Bhartiya US, Raut YS, Hawaldar RW, Nayak Y, Pawar YP, et al. Federal government websites often end in .gov or .mil. Bast F, Rani P, Meena D. Chloroplast DNA phylogeography of holy basil (Ocimum tenuiflorum) in Indian subcontinent. The predominant cause of global morbidity and mortality is lifestyle-related chronic diseases, many of which can be addressed through Ayurveda with its focus on healthy lifestyle practices and regular consumption of adaptogenic herbs. Mishra M. Tulsi to Save Taj Mahal from Pollution Effects. This has been highlighted in a recent United Nations document titled Wake Up Before It's Too Late, which calls for the global community to endorse and advocate for local solutions to toxicity, food insecurity and poverty, such as the use of organic and small-scale farming over the use of genetically modified organisms and monocultures. For example, sophisticated Asian tea ceremonies involve a whole set of rituals, tools and gestures that serve to transcend normal consciousness, while in the west the ritual of afternoon tea or high tea emphasizes the surroundings, equipment, manners and social circle. The placing of a living tulsi plant at the center of the household, therefore, has applicability beyond the realms of Hinduism and may play a useful role in addressing modern day issues through embodying the healing power of the natural world and serving as a constant connection to living nature. Deo SS, Inam F, Mahashabde RP. Similarly, in human clinical trials, tulsi has shown to decrease glucose levels, improve blood pressure and lipid profiles[54,55,56] and reduce many diabetic symptoms in patients with type 2 diabetes. [130], It is also important to ensure the correct herb is used and that manufacturers adopt stringent quality assurance standards and processes. Furthermore, tulsi does not produce the same physical dependence as caffeine and can be safely consumed on a regular basis without the fear of withdrawal effects. Monga J, Sharma M, Tailor N, Ganesh N. Antimelanoma and radioprotective activity of alcoholic aqueous extract of different species of Ocimum in C (57) BL mice. Wani NS, Bhalerao AK, Ranaware VP, Zanje R. Formulation and evaluation of herbal sanitizer. Anti tuberculosis effect of, Shokeen P, Ray K, Bala M, Tandon V. Preliminary studies on activity of. While the concept of an adaptogen, or herb that helps with the adaptation to stress and the promotion of homeostasis, is not widely used in Western medicine, Western science has revealed that tulsi does indeed possess many pharmacological actions that fulfill this purpose. (TULSI)-an overview. Chandra R, Dwivedi V, Shivam K, Jha AK. Tulsi has also been used in cities to combat air pollution and hundreds of thousands of tulsi plants have been planted around the Taj Mahal in Agra to help protect the iconic marble building from environmental pollution damage. National Library of Medicine Prolonged physical exertion, physical restraint, exposure to cold and excessive noise disturb homeostasis by inducing physiological and metabolic stress. [3,4,5,6] In addition to these health-promoting properties, tulsi is recommended as a treatment for a range of conditions including anxiety, cough, asthma, diarrhea, fever, dysentery, arthritis, eye diseases, otalgia, indigestion, hiccups, vomiting, gastric, cardiac and genitourinary disorders, back pain, skin diseases, ringworm, insect, snake and scorpion bites and malaria.[3,5,6,7]. Suanarunsawat T, Ayutthaya WD, Songsak T, Thirawarapan S, Poungshompoo S. Lipid-lowering and antioxidative activities of aqueous extracts of Ocimum sanctum L. leaves in rats fed with a high-cholesterol diet. Effect of Ocimum sanctum on homocysteine levels and lipid profile in healthy rabbits. Joshi H, Parle M. Cholinergic basis of memory improving effect of, Bhattacharyya D, Sur TK, Jana U, Debnath PK. Sharmila Banu G, Kumar G, Murugesan AG. Many of the physiological benefits of tulsi can be attributed to its ability to assist with the body's internal housekeeping and protection of the body from toxin-induced damage. [3] Within India, tulsi has been adopted into spiritual rituals and lifestyle practices that provide a vast array of health benefits that are just beginning to be confirmed by modern science. Effect of Ocimum sanctum extract on sodium nitrite-induced experimental amnesia in mice. In providing a focus for ethical, sustainable and ecological farming practices that provides a livelihood for thousands of farmers, the cultivation of tulsi goes beyond providing benefits for individuals and households and begins to address broader social, economic and environmental issues. Biological activities of Ocimum sanctum L. fixed oil--an overview. Hannan JM, Marenah L, Ali L, Rokeya B, Flatt PR, Abdel-Wahab YH. Children and Nature 2008. Selective toxicity of. 2013. pp. [48] Tulsi has also been shown to improve lipid profiles,[49,50] prevent weight gain, hyperglycemia, hyperinsulinemia, hypertriglyceridemia and insulin resistance,[51,52] and protect the organs and blood vessels from atherosclerosis[49,53] in laboratory animals fed high-fat diets. Bharath BK, Anjaneyulu Y, Srilatha C. Imuuno-modulatory effect of. Singh S, Taneja M, Majumdar DK. The Times of India, Bennett Coleman and Co. Ltd. Maller C, Townsend M, St Leger L, Henerson-Wilson C, Pryor A, Prosser L, et al. The Ocimum sanctum Linn. Randomized placebo-controlled, single blind trial of holy basil leaves in patients with noninsulin-dependent diabetes mellitus. Daily consumption of tulsi is said to prevent disease, promote general health, wellbeing and longevity and assist in dealing with the stresses of daily life. Dahiya K, Sethi J, Dhankhar R, Singh V, Singh SB, Yadav M, et al. Uma Devi P, Ganasoundari A, Vrinda B, Srinivasan KK, Unnikrishnan MK. Immunomodulating effect of, Bora DS, Khanikor B. While modern scientific studies suggest that tulsi is effective in treating a range of stressful conditions, within Ayurveda, tulsi is more commonly recommended as a preventive measure to enhance the ability to adapt to both psychological and physical stress and therefore prevent the development of stress-related diseases. Role of Ocimum sanctum in the experimental model of Alzheimer's disease in rats. A study of hepatoprotective activity of Ocimum sanctum (Krishna tulas) extracts in chemically induced liver damage in albino mice. A review of the scientific literature on the health benefits of connection to nature suggest that access to nature plays a vital role in human health, wellbeing and development that has not been fully recognized,[128] and there is now a global movement to reconnect people with nature that has arisen out of concerns over nature deficit, sedentary lifestyles, obesity, mental health issues, excessive use of electronic media, environmental degradation, wildlife conservation, sustainability and climate change.[129]. Wangcharoen W, Morasuk W. Antioxidant capacity and phenolic content of holy basil. Siddique YH, Ara G, Beg T, Afzal M. Anti-genotoxic effect of, Jha AK, Jha M, Kaur J. Ethanolic extracts of, Manikandan P, Vidjaya Letchoumy P, Prathiba D, Nagini S. Combinatorial chemopreventive effect of Azadirachta indica and, Rastogi S, Shukla Y, Paul BN, Chowdhuri DK, Khanna SK, Das M. Protective effect of. Ayurveda's use of medicinal and culinary herbs draws upon India's incredible biodiversity with a variety that is unsurpassed by any medical system; yet, of all the herbs used, none has a status comparable to tulsi or holy basil (Ocimum sanctum). Healthy parks, healthy people: The health benefits of contact with nature in a park context. Development and biological evaluation of herbal anti-acne gel. [105,106] This has been confirmed in clinical trials that have demonstrated that rinsing with tulsi is as effective as 0.2% Chlorhexidine and Listerine in reducing the levels of Streptococcus mutans[107] and that a herbal mouthwash that includes tulsi is preferred for its taste and convenience. Regular consumption of tulsi tea may be compared with the regular practice of yoga, which can be considered adaptogenic through nurturing and nourishing the body -- mind -- spirit while fostering a sense of relaxation and wellbeing. Yet, while tea and coffee have infiltrated their way into modern living, they have not yet attained the status that tulsi has within traditional Indian life. [78] While no human trials have been published, there is experimental evidence that tulsi may help in the treatment of various human bacterial infections including urinary tract infections,[79] skin and wound infections,[80] typhoid fever,[81] cholera,[82] tuberculosis,[83] gonorrhea,[84] acne,[85] herpes simplex,[86] leishmaniasis,[87] various pneumonias[88] and fungal infections,[89,90,91,92] as well as mosquito-borne diseases such as dengue, malaria and filariasis. Enhancing chloramphenicol and trimethoprim, Parag S, Vijyayshree N, Rami B, Patil B. Antibacterial activity of, Farivar TN, Fard AH, Zahedani SS, Naderi M, Moud BS. For example, it is suggested that tulsi should be grown employing organic methods in rural areas free from environmental pollution. Shah K, Verma RJ. These studies attest to the ability of tulsi to prevent liver, kidney and brain injury by protecting against the genetic, immune and cellular damage caused by pesticides, pharmaceuticals and industrial chemicals. In addition to sanctifying the home, tulsi is used ceremonially in Hinduism and some Greek Orthodox Churches to create holy water. Tulsi wood or seeds are also used to make tulsi malas, which are strings of beads used to help the mind focus during meditation, chanting and devotional practices and therefore ceremonially connect mind, body and spirit. Effect of Ocimum sanctum fixed oil on vascular permeability and leucocytes migration. Leishmanicidal active constituents from Nepalese medicinal plant Tulsi (, Saini A, Sharma S, Chhibber S. Induction of resistance to respiratory tract infection with Klebsiella pneumoniae in mice fed on a diet supplemented with tulsi (. Despite the many wonders of science and industry, modern life is fraught with stress. Metabolic syndrome, also known as prediabetes or Syndrome X, includes the deadly quartet of centripetal obesity, hypertension, high cholesterol and poor glucose regulation and is associated with chronic inflammation and a greater risk of diabetes, heart disease and stroke. leaf extract on healthy volunteers. Verma P, Kedia DK, Nath A. Effect of Ocimum sanctum Linn on the changes in central cholinergic system induced by acute noise stress. The site is secure. Considered as a potent adaptogen, tulsi has a unique combination of pharmacological actions that promote wellbeing and resilience. Anxiolytic effect of acute administration of ursolic acid in rats. on gastric mucosal offensive and defensive factors. government site. The drinking of tea and coffee has become an integral part of modern life and has been ritualized in many cultures to guide social interactions, set social agendas and invoke spiritual awareness. Evaluation of antiinflammatory activity of fatty acids of. Singh N, Verma P, Pandey BR, Bhalla M. Therapeutic Potential of. Protection of mouse bone marrow against radiation-induced chromosome damage and stem cell death by the ocimum flavonoids orientin and vicenin. Singh PK, Baxi D, Banerjee S, Ramachandran AV. Samson J, Sheeladevi R, Ravindran R. Oxidative stress in brain and antioxidant activity of Ocimum sanctum in noise exposure. Like yoga, tulsi has a calming effect that leads to clarity of thought, along with a more relaxed and calm disposition. Before Antioxidant and cyclooxygenase inhibitory phenolic compounds from, Kalabharathi HL, Suresha RN, Pragathi B, Pushpa VH, Satish AM. Devra DK, Mathur KC, Agrawal RP, Bhadu I, Goyal S, Agarwal V. Effect of tulsi (, Kochhar A, Sharma N, Sachdeva R. Effect of supplementation of Tulsi (. Suanarunsawat T, Songsak T. Anti-hyperglycaemic and anti-dyslipidaemic effect of dietary supplement of white Ocimum Sanctum Linnean before and after STZ-induced diabetes mellitus. Trade and Environment Review 2013. Asian J Microbiol Biotechnol Environ Sci. We are in the midst of a global pandemic of obesity, diabetes, cancer, dementia, depression and other chronic diseases caused by modern lifestyles and their associated lack of physical activity, high intake of sugar, fat, salt, alcohol and tobacco and exposure to a toxic cocktail of industrial chemicals. The psychotherapeutic properties of tulsi have been explored in various animal experiments that reveal that tulsi has anti-anxiety and anti-depressant properties,[116,117,118] with effects comparable to diazepam and antidepressants drugs. Ltd., which is a company that manufactures and distributes tulsi products. Adaptogen, Ayurveda, holy basil, lifestyle. PMC legacy view Bhartiya US, Raut YS, Joseph LJ. Accessibility Thus, tulsi has been shown to protect against the toxic effects of industrial chemicals such as butylparaben,[16] carbon tetrachloride,[17] copper sulfate[18] and ethanol,[19] and common pesticides such as rogor,[20] chlorpyrifos,[21] endosulfan[22] and lindane. Effect of Ocimum sanctum leaf powder on blood lipoproteins, glycated proteins and total amino acids in patients with non-insulin-dependent diabetes mellitus. Shyamala AC, Devaki T. Studies on peroxidation in rats ingesting copper sulphate and effect of subsequent treatment with, Bawankule DU, Pal A, Gupta S, Yadav S, Misra A, Rastogi S, et al. Trace elements in typical herbs as an indicator of environmental pollution. Studies using diabetic laboratory animals have shown that tulsi can reduce blood glucose, correct abnormal lipid profiles[46,47] and protect the liver and kidneys from the metabolic damage caused by high glucose levels.
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